Abstract: By mechanical properties tests and microstructure observation,the strengthening of V-4Cr-4Ti alloys by aging and cold-woking was studied,along with the way of cold-work and oxygen influenced the aging process. The results showed the Ti-(C,O,N) precipitates were produced during the aging process,and 650℃/3 h was the very aging condition that V-4Cr-4Ti alloys can get better mechanical performance. An aging plus cold-working process can further strengthen the alloys. What's more,the strengthening of aging could be affected by the pre-cold-working and the oxygen concentration in the alloy.