Abstract: The joints of Ti60 and TC17 are welded by electron beam welding, the macrostructure, microstructure and microhardness of the joints were analyzed. The results showed that the microstructure of the welding seam was consisted of the symmetric dendrites; and the microstructure of heat affected zone near Ti60 side was speculate α phase, which had a clear boundary with a welding line; and TC17 side was consisted of fine granular α phase. The hardness of the welding seam was higher than that of the base metal.